Case Report June 14, 2022

A Case and Proposed Mechanism of Catatonia During the Post-Acute Phase of Severe Acute Respiratory Syndrome Coronavirus 2 Infection

David R. Spiegel, MD; Alice Kisteneff, MD; Whitney Fidelis, BA; Jenna Frawley, BS; Daniel Connelly, BS; Abbey McLean, MD; Aaron Lopacinski, BS; Nicole Crofton, BS; Callie Dacyczyn, BS; Ann Ayzman, BS; Bradley Conlin, BS; Andrew Rickelmann, BS; Merete Lund, BS; Vanessa Rave, MS

Prim Care Companion CNS Disord 2022;24(3):21cr03233

Continue Reading...

Did you know members enjoy unlimited free PDF downloads as part of their subscription? Subscribe today for instant access to this article and our entire library in your preferred format. Alternatively, you can purchase the PDF of this article individually.

Subscribe Now

Already a member? Login

Purchase PDF for $40

Members enjoy free PDF downloads on all articles. Join today

  1. Gouse BM, Spears WE, Nieves Archibald A, et al. Catatonia in a hospitalized patient with COVID-19 and proposed immune-mediated mechanism. Brain Behav Immun. 2020;89:529–530. PubMed CrossRef
  2. Scheiner NS, Smith AK, Wohlleber M, et al. COVID-19 and catatonia: a case series and systematic review of existing literature. J Acad Consult Liaison Psychiatry. 2021;62(6):645–656. PubMed CrossRef
  3. Varatharaj A, Thomas N, Ellul MA, et al; CoroNerve Study Group. Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study. (Published correction appears in Lancet Psychiatry. July 14, 2020.) Lancet Psychiatry. 2020;7(10):875–882. PubMed CrossRef
  4. Bush G, Fink M, Petrides G, et al. Catatonia, I: rating scale and standardized examination. Acta Psychiatr Scand. 1996;93(2):129–136. PubMed CrossRef
  5. Caan MP, Lim CT, Howard M. A case of catatonia in a man with COVID-19. Psychosomatics. 2020;61(5):556–560. PubMed CrossRef
  6. Deocleciano de Araujo C, Schlittler LXC, Sguario RM, et al. Life-threatening catatonia associated with coronavirus disease 2019. J Acad Consult Liaison Psychiatry. 2021;62(2):256–257. PubMed CrossRef
  7. Vazquez-Guevara D, Badial-Ochoa S, Caceres-Rajo KM, et al. Catatonic syndrome as the presentation of encephalitis in association with COVID-19. BMJ Case Rep. 2021;14(6):e240550. PubMed CrossRef
  8. Fiaschè F, Adriani B, Mancinelli I, et al. Treatment of catatonia with asenapine in a patient with schizotypal personality disorder, psychotic depression and septic shock from SARS-CoV-2: a case report. CNS Neurol Disord Drug Targets. 2021;20(5):473–477. PubMed CrossRef
  9. Zain SM, Muthukanagaraj P, Rahman N. Excited catatonia: a delayed neuropsychiatric complication of COVID-19 infection. Cureus. 2021;13(3):e13891. PubMed CrossRef
  10. Torrico T, Kiong T, D’Assumpcao C, et al. Postinfectious COVID-19 catatonia: a report of two cases. Front Psychiatry. 2021;12:696347. PubMed CrossRef
  11. Mulder J, Feresiadou A, Fällmar D, et al. Autoimmune encephalitis presenting with malignant catatonia in a 40-year-old male patient with COVID-19. Am J Psychiatry. 2021;178(6):485–489. PubMed CrossRef
  12. Zandifar A, Badrfam R. Exacerbation of psychosis accompanied by seizure and catatonia in a patient with COVID-19: a case report. Psychiatry Clin Neurosci. 2021;75(2):63–64. PubMed CrossRef
  13. Amouri J, Andrews PS, Heckers S, et al. A case of concurrent delirium and catatonia in a woman with coronavirus disease 2019. J Acad Consult Liaison Psychiatry. 2021;62(1):109–114. PubMed CrossRef
  14. Austgen G, Meyers MS, Gordon M, et al. The use of electroconvulsive therapy in neuropsychiatric complications of coronavirus disease 2019: a systematic literature review and case report. J Acad Consult Liaison Psychiatry. 2022;63(1):86–93. PubMed CrossRef
  15. Kwon HJ, Patel KH, Ramirez M, et al. A case of fatal catatonia in a COVID-19 patient. Cureus. 2021;13(7):e16529. PubMed CrossRef
  16. Wu Y, Xu X, Chen Z, et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020;87:18–22. PubMed CrossRef
  17. Nalleballe K, Reddy Onteddu S, Sharma R, et al. Spectrum of neuropsychiatric manifestations in COVID-19. Brain Behav Immun. 2020;88:71–74. PubMed CrossRef
  18. Nezgovorova V, Ferretti CJ, Pallanti S, et al. Modulating neuroinflammation in COVID-19 patients with obsessive-compulsive disorder. J Psychiatr Res. 2022;149:367–373. PubMed CrossRef
  19. Fusunyan M, Praschan N, Fricchione G, et al. Akinetic mutism and coronavirus disease 2019: a narrative review. J Acad Consult Liaison Psychiatry. 2021;62(6):625–633. PubMed CrossRef
  20. Zhou Z, Kang H, Li S, et al. Understanding the neurotropic characteristics of SARS-CoV-2: from neurological manifestations of COVID-19 to potential neurotropic mechanisms. J Neurol. 2020;267(8):2179–2184. PubMed CrossRef
  21. Boldrini M, Canoll PD, Klein RS. How COVID-19 affects the brain. JAMA Psychiatry. 2021;78(6):682–683. PubMed CrossRef
  22. Gubernatorova EO, Gorshkova EA, Polinova AI, et al. IL-6: relevance for immunopathology of SARS-CoV-2. Cytokine Growth Factor Rev. 2020;53:13–24. PubMed CrossRef
  23. Meinhardt J, Radke J, Dittmayer C, et al. Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19. Nat Neurosci. 2021;24(2):168–175. PubMed CrossRef
  24. Rustad JK, Landsman HS, Ivkovic A, et al. Catatonia: an approach to diagnosis and treatment. Prim Care Companion CNS Disord. 2018;20(1):17f02202. PubMed CrossRef
  25. Bartolommei N, Lattanzi L, Callari A, et al. Catatonia: a critical review and therapeutic recommendations. J Psychopathology. 2012;18:234–246.