Primary Care Companion for CNS Disorders Primary Care Companion for CNS Disorders

The Primary
Care Companionfor CNS Disorders

Advancing primary care with essential peer-reviewed research and insights into CNS disorders

Back to top Open menu arrow
Current Issue Archives Authors Reviewers

Just Published

PCC
Zeroing in on Xylazine
Letter to the Editor

August 15, 2024

The authors discuss the need to raise awareness among US public and health care professionals about xylazine due to its infiltration into the illicit drug supply.
Jasleen Kaur, Megan Nosol, Vania Modesto-Lowe
PCC
Delusional Disorder and PMDD With Antipsychotic-Induced Hyperprolactinemia
Case Report

August 15, 2024

A patient diagnosed with PMDD developed delusional disorder, with marked variability in symptom severity correlating with the menstrual cycle, as well as hyperprolactinemia after starting antipsychotic treatment.
Tanvi Mittal, Nishanth Jalaja Haridas
PCC
Dementia Mortality Patterns in the United States
Original Research

August 13, 2024

This study analyzed contemporary trends of dementia and dementia-related mortality in the United States between 1999 and 2020 categorized by demographic and regional attributes.
Mohsan Ali, Muhammad Talha, Bisal Naseer, et al

Vol 26 • 2024 • Number 4

Read the Current Issue

Narrative Review

Management of ADHD in Adolescents and Young Adults

Narrative Review

Tech Gaming Designs, Neurodevelopmental Vulnerabilities, and Internet Gaming Disorder Risk

Original Research

Presentation and Outcome of MCI

Original Research

Dementia Mortality Patterns in the United States

Rounds in the General Hospital

Pharmacologic Management of TBI

Rounds in the General Hospital

Evaluation and Management of Treatment-Resistant Schizophrenia
View current Issue

Explore Special Sections

View all topics

Original Research

PCC
Liver Failure and Transplant After Excessive Energy Drink Consumption
Case Report

January 16, 2024

A 21-year-old man developed acute liver failure and cerebral edema following a binge episode of energy drink consumption.
Brett D. Jesse, Nam V. Nguyen, Alëna A. Balasanova
PCC
Children With ADHD During the COVID-19 Pandemic
Original Research

January 2, 2024

Stresses caused by the COVID-19 pandemic may negatively affect management of ADHD in youth. This study assessed the perceived impact of the COVID-19 pandemic on treatment and quality of…
Subhara Raveendran, Mary C. Burke, Karen Klahn, et al
PCC
Prescription Bupropion Misuse
Case Report

November 21, 2023

Bupropion is considered a substance of low abuse potential. This report describes a case of bupropion misuse leading to mania in a patient with attention-deficit/hyperactivity disorder.
Greg Noe, Samantha Ongchuan Martin, Kaushal Shah, et al

Review Articles

PCC
Alternative Treatment for Agitation in Schizophrenia and Bipolar Disorder
Narrative Review

January 30, 2024

While oral and intramuscular formulations of pharmacologic agents continue to be commonly used to treat acute agitation, novel agents with alternative routes of delivery are becoming available.
Leslie Citrome, Christoph U. Correll, Luis San, et al
PCC
Neuropsychiatric Manifestations and Management of Tuberous Sclerosis
Narrative Review

January 4, 2024

Ninety percent of individuals with tuberous sclerosis have associated neuropsychiatric manifestations including ADHD, autism spectrum disorder, and intellectual disability, which are typically underidentified and undertreated.
Parul Gupta, Mamidipalli Sai Spoorthy, Pooja R. Raikar
PCC
Fentanyl-Contaminated Oxycodone
Narrative Review

November 9, 2023

The growing use of fentanyl-contaminated products is fueling the US opioid crisis. This study reviewed the rising prevalence of nonprescription fentanyl in counterfeit oxycodone, paying specific attention to oxycodone…
Grace E. Hartmann, Roopa Sethi
PCC
Structural Racism and Telepsychiatry During the COVID-19 Pandemic
Review Article

November 2, 2023

Data on whether psychiatry can be practiced effectively via telephone are lacking. This study examined the racial and sociodemographic distribution of people receiving audiovisual versus audio-only telepsychiatry since the…
Tashalee R. Brown, Kevin Y. Xu, Anne L. Glowinski
PCC
Xylazine as a Fentanyl Adulterant in the US
Narrative Review

October 31, 2023

Data obtained from studies between 2006 and 2022 indicate a rapidly increasing incidence of xylazine overdose in the United States, with overdose cases now being seen in 25 states.
Caitlin E. Leconte, Roopa Sethi
PCC
rTMS in Depression, Schizophrenia, and OCD
Meta-Analysis

September 26, 2023

In treatment-resistant depression, repetitive transcranial magnetic stimulation had higher odds of response and remission rates compared to sham.
Shweta Patel, Suraiya Silvi, Saral Desai, et al

Rounds in the General Hospital

PCC
Clozapine: Its Use and Monitoring
Rounds in the General Hospital

July 30, 2024

The authors provide the latest information on clozapine use, including when your patients should receive or avoid taking it, what laboratory tests are required before and during administration, and…
Desta S. Lissanu, Chirag M. Vyas, Carol S. Lim, et al
PCC
Neuropsychiatric Complications of Hypervitaminosis D
Rounds in the General Hospital

June 13, 2024

A 28-year-old man presented to the emergency department with severe agitation, insomnia, weakness, constipation, and muscle jerks after nonsuicidal overdosing of vitamin D.
James K. Rustad, Adam Z. Spitz, Brandon C. Wilson, et al
PCC
Impact of Disability on Medical Care
Rounds in the General Hospital

June 6, 2024

Given that many people have disabilities, physicians should develop skills that assess the level of disability, the functional consequence of illness, and the social and physical environments of patients…
Mirza Baig, Andrew S. Chun, Ashika Bains, et al
PCC
Management of Rumination and Obsessions in Primary Care
Rounds in the General Hospital

May 30, 2024

Difficult-to-control negative repetitive thoughts can manifest as ruminations or obsessions. Appropriate early identification and intervention can positively affect the course and prevent an episode of psychiatric illness.
Sharmin Ghaznavi, Charlotte Schiewe, Theodore A. Stern
PCC
Strategies for Cutting Down and Stopping Alcohol Use
Rounds in the General Hospital

May 28, 2024

Knowledge of nonpharmacologic approaches as well as medications’ mechanisms of action, side effects, and drug-drug interactions can facilitate the timely and appropriate use of psychotropics to help individuals cut…
Sofia E. Matta, Olga Terechin, Arwen Podesta, et al
PCC
Medical Uses and Adverse Effects of Psilocybin
Rounds in the General Hospital

May 28, 2024

There has been a resurgence of interest in the use of psychedelics, including psilocybin, for therapeutic purposes, with early studies suggesting promise for use in various conditions such as…
Sharmin Ghaznavi, Lourdes M. Bernardez, Theodore A. Stern

Case Reports

PCC
Sexsomnia and Dhat Syndrome in an Adolescent Male
Case Report

August 8, 2024

A 17-year-old boy presented with sexsomnia and Dhat syndrome, a culture-bound syndrome characterized by excessive concerns about semen loss and its perceived health consequences.
Tanvi Mittal, Nishanth Jalaja Haridas
PCC
Steroid-Induced Musical Hallucinosis
Case Report

August 8, 2024

A 59-year-old man with no prior psychiatric history developed musical hallucinations following the administration of methylprednisolone.
Jon Sole, Shixie Jiang, Matthew Gunther
PCC
Allopurinol for Resistant Mania
Case Report

August 1, 2024

This case report contributes to evidence supporting the therapeutic effectiveness of allopurinol in managing a complex clinical presentation involving comorbid mania, hyperuricemia, and gout.
Satish Suhas, Dhritiman Das, Channaveerachari N. Kumar
PCC
Catatonia in a Patient With Hypothyroidism Due to Levothyroxine Nonadherence
Case Report

August 1, 2024

The authors present a case of catatonia in the context of a 72-year-old patient with nonadherence to thyroxine who developed severe hypothyroidism.
David R. Spiegel, Conor Jahelka, Morgan Shelton, et al
PCC
ECT for Catatonia With NPSLE, Epilepsy, and Cerebral Palsy
Case Report

July 25, 2024

The authors discuss a patient with neuropsychiatric systemic lupus erythematosus, epilepsy, and cerebral palsy who developed benzodiazepine-refractory catatonia and immunosuppression with complete resolution of symptoms after 20 ECT treatments.
Tyler J. Thompson, Benjamin D. Smart, Heather E. Douglas, et al
PCC
Hallucinations Following IV Tapentadol Use
Case Report

July 23, 2024

The authors describe 2 cases of individuals who developed tapentadol-induced hallucinations in clear consciousness following nonprescribed intravenous use.
Gaurav Kumar Singh, Abhishek Khatri, Ateev Sudhir Chandna, et al

Letter to the Editor

PCC
A Mnemonic for Psychiatric History of Presenting Illness
Letter to the Editor

July 18, 2024

In this letter to the editor, the author presents a mnemonic created to help clinicians obtain a psychiatric history.
Abdulsamad A. Aljeshi
PCC
Suicide Attempts in Gambling Disorder
Letter to the Editor

July 4, 2024

Drs Chamberlain and Grant investigate history of suicide attempts among treatment-seeking individuals with gambling disorder who participated in clinical trials in the US.
Samuel R. Chamberlain, Jon E. Grant
PCC
SSRI-Related Sexual Dysfunction
Letter to the Editor

June 20, 2024

The authors discuss 2 SSRI-related sexual dysfunction syndromes: post-SSRI sexual dysfunction and persistent genital arousal disorder.
Ahmed Naguy, Bibi Alamiri
PCC
Other Nonspecified Feeding or Eating Disorders: Pushing the Envelope
Letter to the Editor

June 18, 2024

The authors shed some light on a wide array of disturbed eating behaviors that defy current nosological and taxonomic boundaries and need further clarification.
Ahmed Naguy, Bibi Alamiri
PCC
Intersection of ChatGPT and Reddit
Letter to the Editor

June 4, 2024

The authors discuss the interplay of online social media support groups and interactive chatbots, which may represent a new realm of mental health support.
Kripa Ahuja, Grace DeSena, David Spiegel
PCC
An Initiative to Combat Addiction Stigma in Medical Education
Letter to the Editor

May 21, 2024

The authors describe the creation and implementation of a unique online module to address the stigma of addiction in a medical school curriculum.
Zoha Baig, Giselle Appel, Zoe Verzani, et al

More PCC Articles

JCP
SSRI Discontinuation and AUD Relapse
Case Report

August 26, 2024

A man with AUD achieves sobriety on treatment with an SSRI and naltrexone, but then stops taking the SSRI to participate in a psilocybin “ceremony.” What factors contributed to…
Mark A. Frye, Balwinder Singh, Scott A. Breitinger, et al
JCP
Reproductive Pharmacovigilance and Best Practices
Commentary

August 26, 2024

Dr Freeman discusses a recent study by Pacilio et al that characterized real world practices around ketamine treatment and pregnancy testing, consent processes, and contraception use. She emphasizes the…
Marlene P. Freeman
JCP
Olanzapine and Mirtazapine for Cancer-Related Anorexia
Clinical and Practical Psychopharmacology

August 21, 2024

Dr Andrade discusses two RCTs that investigated the utility of olanzapine and mirtazapine in addressing appetite loss in cancer patients.
Chittaranjan Andrade
JCP
Economic Impact of Cognitive Impairment and Negative Symptoms in Schizophrenia
Review Article

August 21, 2024

Patients with schizophrenia and cognitive impairment had a 100% increase in relapse-related hospitalizations and ER visits versus patients with no (or only mild) cognitive impairment.
Christoph U. Correll, Pin Xiang, Kaushik Sarikonda, et al
JCP
Functional Unblinding in Pivotal Studies and the Future of Psychedelic Medicine
Commentary

August 21, 2024

Dr Rosenbaum comments on the challenge of evaluating trials of treatments whose effects are unmistakable, and how this dilemma may be addressed.
Jerrold F. Rosenbaum
JCP
Adjunctive Treatment Targeting Multiple Mechanisms in Schizophrenia
Narrative Review

August 19, 2024

While the pathophysiology of schizophrenia is complex, treatments with novel pharmacological actions that target these systems are of interest as adjunctive treatment for schizophrenia.
Bruce J. Kinon, Stefan Leucht, Carol Tamminga, et al
JCP
Prevalence and Course of Unwanted, Intrusive Thoughts of Infant-Related Harm
Original Research

August 14, 2024

Although intrusive thoughts of accidental and intentional infant harm are a common and normative postpartum experience, they cause distress for many new mothers. Clinically significant symptoms that remain by…
Fanie Collardeau, Olivia L. U. Anglin, Arianne Y. K. Albert, et al
JCP
Differentiation Across Bipolar Disorder and MDD by Whole-Night Polysomnographic Findings
Original Research

August 14, 2024

PSG-measured sleep abnormalities, such as reduced REM latency, may be a diagnostic differentiating factor between MDD and bipolar disorder.
Meihong Xiu, Wenxin Li, Yu Lan, et al
JCP
Aripiprazole Lauroxil Initiation Regimens
Original Research

August 12, 2024

In separate studies of the two initiation methods, the numbers of people who had side effects were similar, and most side effects were mild.
Roger W. Sommi, Stephen R. Saklad, Peter J. Weiden, et al
JCP
Symptomatic Disorders Comorbid with Borderline Personality Disorder Over Time
Original Research

August 7, 2024

Findings suggest that the absence of substance use disorders is the strongest predictor of achieving recovery from BPD.
Mary C. Zanarini, Frances R. Frankenburg, Isabel V. Glass, et al
JCP
Predictive Validity of Early Post-Injury CAPS-5 Score for Later PTSD Diagnosis
Original Research

August 5, 2024

A CAPS-5 score of ≥15 provided good predictive accuracy for subsequent PTSD development in the general injured population.
Jae-Min Kim, Ju-Wan Kim, Hee-Ju Kang, et al
JCP
Sleep Disturbances and Perceived Stress in Substance Use Disorder Treatment
Original Research

July 31, 2024

Higher stress was associated with more severe insomnia, and vice versa, both at treatment intake and over the course of treatment, regardless of primary substance.
Martin Hochheimer, Jennifer D. Ellis, Brion Maher, et al

Celebrating
85 Years

Read the Journal of Clinical Psychiatry

Subscribe to read
more articles

Subscribe