Chlorpromazine-Induced Skin Pigmentation With Short-Term Use in a Patient With Bipolar Disorder: A Case Report

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Sir: Chlorpromazine is known, in rare instances, to induceskin pigmentation in areas exposed to sunlight.¹ The prevalencein chronic, hospitalized patients is reported as 1.0% to 2.9%.²Some authors report chlorpromazine-induced skin pigmentationas irreversible,³ while some findings⁴ indicate that it is completelyreversible and that a variety of neuroleptics, includingother phenothiazines, are used to replace chlorpromazine withoutrisk of reemergence of pigmentation.⁴