Lisdexamfetamine and Secondary Raynaud's Phenomenon

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To the Editor: Raynaud’s phenomenon is a clinical disorder characterized by episodic spasm or vasoconstriction of the arteries and smaller arterioles of the extremities, such as the fingers and toes or ears and nose, usually in response to cold or emotional stimuli. This disorder is also exacerbated by smoking. A classic attack is evidenced by the pallor of the distal extremity followed by cyanosis and then redness and paresthesia.