Methylphenidate-Induced Akathisia in a Patient With Multiple Sclerosis

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Sir: Methylphenidate is a short-acting psychostimulant thatis structurally and pharmacologically similar to dextroamphetamineand is primarily used in the treatment of attention-deficit/hyperactivity disorder (ADHD).^1,2 Its use has also been exploredfor the treatment of apathy and for augmentation ofeffects of antidepressants.³ It acts as a dopaminergic and noradrenergicreuptake inhibitor.