Advancing primary care with essential peer-reviewed research and insights into CNS disorders
Rounds in the General Hospital
Rounds in the General Hospital
Management of Rumination and Obsessions in Primary Care
May 30, 2024
Difficult-to-control negative repetitive thoughts can manifest as ruminations or obsessions. Appropriate early identification and intervention can positively affect the course and prevent an episode of psychiatric illness.
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Clinical and Practical Psychopharmacology
Gestational Exposure to Benzodiazepines and Z-Hypnotics and Risk of Adverse Pregnancy Outcomes
April 3, 2023
Chittaranjan Andrade, MD, discusses recent studies on exposure to benzodiazepines and hypnotics and risk of major congenital malformation and other adverse pregnancy outcomes.
Original Research
Generalizability of RCTs in First-Episode Schizophrenia
March 29, 2023
First-episode schizophrenia patients with suicidal ideation and substance use disorder are often excluded from clinical trials. Omitting them does not affect key outcome measures but excludes many potential subjects.
Meta-Analysis
Mechanisms of Treatment of Bipolar Disorder and Borderline Personality Disorder: Brain Imaging Research
March 27, 2023
Different brain regions were changed with psychotherapy versus medication. The findings may help with predicting treatment efficacy and identifying treatment biomarkers in these disorders.
Original Research
Olanzapine/Samidorphan Mitigates Weight Gain in Early Illness
March 22, 2023
In patients with early-phase schizophrenia or bipolar disorder, combination olanzapine and samidorphan resulted in less weight gain at week 12 than olanzapine alone. Antipsychotic efficacy was similar between the…