Advancing primary care with essential peer-reviewed research and insights into CNS disorders
Rounds in the General Hospital
Rounds in the General Hospital
Management of Rumination and Obsessions in Primary Care
May 30, 2024
Difficult-to-control negative repetitive thoughts can manifest as ruminations or obsessions. Appropriate early identification and intervention can positively affect the course and prevent an episode of psychiatric illness.
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Original Research
Ganaxolone for Persistent Depression
June 9, 2020
Postmenopausal women may be deficient in the neuroactive steroid allopregnanolone. This study examined oral ganaxolone, an allopregnanolone analog, as augmentation therapy in postmenopausal women with inadequate response to traditional…
Original Research
Benzodiazepines, Antidepressants, and Antipsychotics and Mortality in Patients With Dementia
June 2, 2020
Patients with dementia often receive antipsychotics in combination with other psychotropic medications. This study compared mortality for antipsychotics combined with benzodiazepines or antidepressants with that for antipsychotic monotherapy.
Clinical and Practical Psychopharmacology
Major Congenital Malformation Associated With Gestational Exposure to Ondansetron: Weighing the Risks
June 2, 2020
Dr Andrade considers the association between ondansetron use during pregnancy and major congenital malformations. Does confounding by indication explain the findings? And do the benefits conveyed by this medication…
Clinical and Practical Psychopharmacology
Genes as Confounds in Studies of Neurodevelopmental Outcomes After Antidepressant Prescription During Pregnancy
May 26, 2020
Observational studies have found associations between antidepressant drug prescription during pregnancy and autism and ADHD. But is the link actually related to genetic predisposition rather than to the antidepressant?…