Case Report November 21, 2023

“Poor Person’s Cocaine”: Bupropion Insufflation Inducing Manic Symptoms and Its Abuse Potential in Dual Diagnosis Patients

Greg Noe, BS; Samantha Ongchuan Martin, MD; Kaushal Shah, MD, MPH; Sahil Munjal, MD

Prim Care Companion CNS Disord 2023;25(6):23cr03557

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  1. Spera V, Pallucchini A, Carli M, et al. Does cannabis, cocaine and alcohol use impact differently on adult attention deficit/hyperactivity disorder clinical picture? J Clin Med. 2021;10(7):1481. PubMed CrossRef
  2. Langguth B, Hajak G, Landgrebe M, et al. Abuse potential of bupropion nasal insufflation: a case report. J Clin Psychopharmacol. 2009;29(6):618–619. PubMed CrossRef
  3. Welsh CJ, Doyon S. Seizure induced by insufflation of bupropion. N Engl J Med. 2002;347(12):951. PubMed CrossRef
  4. Khurshid KA, Decker DH. Bupropion insufflation in a teenager. J Child Adolesc Psychopharmacol. 2004;14(1):157–158. PubMed CrossRef
  5. Hill S, Sikand H, Lee J. A case report of seizure induced by bupropion nasal insufflation. Prim Care Companion J Clin Psychiatry. 2007;9(1):67–69. PubMed CrossRef
  6. Baribeau D, Araki KF. Intravenous bupropion: a previously undocumented method of abuse of a commonly prescribed antidepressant agent. J Addict Med. 2013;7(3):216–217. PubMed CrossRef
  7. Dwyer S, Hieber R. Mania possibly linked with bupropion for smoking cessation: a case report. Ment Health Clin. 2016;6(6):314–317. PubMed CrossRef
  8. Stahl SM, Pradko JF, Haight BR, et al. A review of the neuropharmacology of bupropion, a dual norepinephrine and dopamine reuptake inhibitor. Prim Care Companion J Clin Psychiatry. 2004;6(4):159–166. PubMed CrossRef
  9. Nomikos GG, Damsma G, Wenkstern D, et al. Acute effects of bupropion on extracellular dopamine concentrations in rat striatum and nucleus accumbens studied by in vivo microdialysis. Neuropsychopharmacology. 1989;2(4):273–279. PubMed CrossRef
  10. Kim D, Steinhart B. Seizures induced by recreational abuse of bupropion tablets via nasal insufflation. CJEM. 2010;12(2):158–161. PubMed CrossRef
  11. Hilliard WT, Barloon L, Farley P, et al. Bupropion diversion and misuse in the correctional facility. J Correct Health Care. 2013;19(3):211–217. PubMed CrossRef