Postpartum Psychosis or Something Else?

Marlee J. Madora, MD; Hallie S. Knopf, MD; Michelle Prakash, MD; Jasmine Kim, BA; Meghana R. Medavaram, MD; Rubiahna L. Vaughn, MD, MPH

Prim Care Companion CNS Disord 2023;25(1):22nr03269

ABSTRACT

Psychosis is a psychiatric emergency that affects up to 1 in 500 women postpartum and can result from various etiologies. We present a case vignette and review of the relevant literature to highlight the broad differential diagnosis of postpartum psychosis with atypical features. Recommendations for evaluation, diagnosis, and treatment of patients with complex neuropsychiatric symptoms in the postpartum period are discussed. This case of postpartum psychosis with malignant catatonia highlights the role of immunology in the development and treatment of postpartum psychosis and the need for future research to more accurately define the etiology and best tailor treatment.

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