Clinical and Practical Psychopharmacology
Page 2
Posts about this type
Clinical and Practical Psychopharmacology
The Practical Importance of Half-Life in Psychopharmacology
July 25, 2022
Essential information on why it’s important to know the half-lives of drugs, how half-life may differ with individual patient characteristics, and how to use this knowledge to best advantage...
Clinical and Practical Psychopharmacology
ADHD, ASD, and Other Neurodevelopmental Outcomes Associated With Antipsychotic Exposure During Pregnancy
May 30, 2022
Dr Andrade discusses the implications of 2 recent large cohort studies examining risk of neurodevelopmental disorders after gestational exposure to antidepressants.
Clinical and Practical Psychopharmacology
Antidepressant Drugs and Health-Related QoL: A Guide to Examining a “Viral” Research Paper
May 25, 2022
A recent study reporting no improvement in health-related quality of life with antidepressants went “viral” in the mass media. Here, Dr Andrade considers the shortcomings of the study and...
Clinical and Practical Psychopharmacology
Insights on Use of Ketamine From RCTs of Ketamine vs Electroconvulsive Therapy in Severe Depression
March 28, 2022
ECT outperformed ketamine in recent randomized controlled trials. These studies also, however, shed light on ketamine’s potential as a viable alternative to ECT in some severely depressed patients.
Clinical and Practical Psychopharmacology
Gestational Exposure to Antidepressants and Neurodevelopment
January 25, 2022
A large new study of youth aged 9–15 years with a history of gestational exposure to antidepressants revealed slightly poorer performance in mathematics, but not in language. Dr Andrade...
Clinical and Practical Psychopharmacology
Limitations of the Odds Ratio in a Case-Control Study of Breast Cancer and Exposure to Antipsychotics
November 23, 2021
Dr Andrade considers the limitations of the odds ratio in a study of prolactin-raising vs prolactin-sparing antipsychotics and breast cancer risk, with the aim of helping readers understand how...
Clinical and Practical Psychopharmacology
Gestational and Neurodevelopmental Outcomes Associated With Exposure to Antipsychotics
October 12, 2021
This article discusses a recent large cohort study of neurodevelopmental outcomes (ADHD, autism) after gestational exposure of antipsychotics—including the limitations of the study.
Clinical and Practical Psychopharmacology
N-Acetylcysteine Augmentation for Patients With Major Depressive Disorder and Bipolar Depression
February 18, 2021
Two recent meta-analyses found little effect of N-acetylcysteine augmentation in MDD or bipolar depression, although some past research has indicated its efficacy. In this article, Dr Andrade takes a...
Clinical and Practical Psychopharmacology
HARKing, Cherry-Picking, P-Hacking, and Data Dredging as Questionable Research Practices
February 18, 2021
In this article, Dr Andrade helps readers identify several types of statistical analysis that violate scientific principles and that researchers may knowingly—or unknowingly—engage in.
Clinical and Practical Psychopharmacology
Paternal Depression as a Risk Factor for Neurodevelopmental Disorders in Offspring
December 1, 2020
Gestational exposure to antidepressants has been associated with risk of autism and ADHD, and a recent study also showed maternal depression as a risk factor. Intriguingly, paternal depression was...
