Clinical and Practical Psychopharmacology
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Clinical and Practical Psychopharmacology
Mean Difference, Standardized Mean Difference, and Their Use in Meta-Analysis
September 22, 2020
Measures and methods used in RCTs vary, so how can we combine their findings to synthesize the evidence? Read this article to gain a better understanding of meta-analysis methodology...
Clinical and Practical Psychopharmacology
Methylphenidate and the Risk of New-Onset Seizures
July 21, 2020
Concerns have been expressed that stimulant drugs may increase seizure risk, but some studies also suggest otherwise. This column considers the findings in the context of the study methodologies...
Clinical and Practical Psychopharmacology
Major Congenital Malformation Associated With Gestational Exposure to Ondansetron: Weighing the Risks
June 2, 2020
Dr Andrade considers the association between ondansetron use during pregnancy and major congenital malformations. Does confounding by indication explain the findings? And do the benefits conveyed by this medication...
Clinical and Practical Psychopharmacology
Genes as Confounds in Studies of Neurodevelopmental Outcomes After Antidepressant Prescription During Pregnancy
May 26, 2020
Observational studies have found associations between antidepressant drug prescription during pregnancy and autism and ADHD. But is the link actually related to genetic predisposition rather than to the antidepressant?...
Clinical and Practical Psychopharmacology
Prenatal Maternal Anemia as a Potential Confound in Studies on Neurodevelopmental and Other Outcomes
March 31, 2020
An association between antidepressants during pregnancy and neurodevelopmental disorders has been found in many observational studies. But is anemia part of the culprit? Dr Andrade takes a closer look...
Clinical and Practical Psychopharmacology
Outcome Measures in a Study of tDCS for Negative Symptoms of Schizophrenia
February 4, 2020
In this article, Dr Andrade provides readers with an understanding of how to critically read a recent study of transcranial direct current stimulation for schizophrenia and demonstrates the importance...
Clinical and Practical Psychopharmacology
An Exercise in the Critical Examination of a Case-Control Study
January 21, 2020
In this month's column, Dr Andrade discusses a recent study suggesting that angiotensin receptor blockers are associated with suicide risk. This critical examination of the study will help readers...
Clinical and Practical Psychopharmacology
Gestational Exposure to Benzodiazepines, Part 3
November 26, 2019
Clobazam is widely used for seizure disorders and anxiety, but its potential teratogenicity has been little discussed in the literature. In this article, Dr Andrade reviews the evidence regarding...
Clinical and Practical Psychopharmacology
Antidepressants and Risk of Hip Fracture in the Elderly
July 30, 2019
Dr Andrade considers the findings of observational studies indicating a higher risk of hip fracture in older people who take antidepressants—and whether confounding by indication can fully explain the...
Clinical and Practical Psychopharmacology
Perspectives on How to Read a Meta-Analysis Critically
May 21, 2019
According to a recent meta-analysis, anti-inflammatory drugs like NSAIDs and statins have an antidepressant effect as well. But do the flaws in the analysis undermine its findings? Dr Andrade...
Clinical and Practical Psychopharmacology
Oral Ketamine for Depression, 1: Pharmacologic Considerations and Clinical Evidence
April 2, 2019
Ketamine has gained visibility recently for its rapid antidepressant effects, but the routes of administration currently in use have drawbacks in terms of cost and inconvenience. In this article,...
Clinical and Practical Psychopharmacology
Antidepressants, Mood Stabilizers, Antipsychotics, and the Risk of Cataract
January 29, 2019
Some studies have indicated that drugs used to treat depression might increase the risk of cataract. This installment of Clinical and Practical Psychopharmacology takes a closer look at the...
Clinical and Practical Psychopharmacology
How to Read a Research Paper: An Exercise in Critical Thinking
December 11, 2018
Tamsulosin, used to treat benign prostatic hyperplasia, was associated in a recent study with an increase in the risk of incident dementia. In this installment of his column, Dr...
