Original Research

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JCP
Original Research

July 3, 2018

Read a randomized control trial evaluating tianeptine's efficacy in patients 65 and older with recurrent major depressive disorder (MDD).
Robin Emsley, Antti Ahokas, Aldo Suarez, et al
JCP
Original Research

June 26, 2018

Reports on the efficacy of omega-3 fatty acids for depression are mixed, with only limited data in adolescents.  This RCT compared their efficacy versus placebo in 51 adolescents with...
Vilma Gabbay, Rachel D. Freed, Carmen M. Alonso, et al
JCP
Original Research

June 26, 2018

Clinical Practice Guidelines have been published by the US military to aid in clinical management of patients with PTSD. To investigate whether these best-practice guidelines are being followed, this...
George Loeffler, Rachael Coller, LaRee Tracy, et al
JCP
Original Research

June 19, 2018

Augmentation of antidepressants with aripiprazole is effective in treating late-life depression. As an antipsychotic medication, however, aripiprazole potentially leads to extrapyramidal side effects (EPS). Read this article to learn...
Jonathan H. Hsu, Benoit H. Mulsant, Eric J. Lenze, et al
JCP
Original Research

June 19, 2018

High rates of schizophrenia symptom recurrence after antipsychotic treatment discontinuation are are thought to be due to withdrawal-related phenomena rather than illness recurrence. This post hoc analysis examines results...
Robin Emsley, Isaac Nuamah, Srihari Gopal, et al
JCP
Original Research

June 12, 2018

Individuals with depression can experience diminished levels of reward positivity (RewP), a neurophysiologic index of reward responsiveness. Can changing levels of RewP be used as an objective index of...
Katie L. Burkhouse, Stephanie M. Gorka, Heide Klumpp, et al
JCP
Original Research

May 29, 2018

Treatment-resistant depression (TRD), broadly defined, is depression not in remission after treatment. About a third of depressed patients lack response to at least one adequate treatment. But how can...
Frederikke Hordam Gronemann, Martin B. Jorgensen, Merete Nordentoft, et al
JCP
Original Research

May 23, 2018

Understanding suicide among military personnel includes identifying risks that are present at enlistment, before exposure to military stressors. This study used survey data from 38,237 soldiers to characterize the...
Murray B. Stein, Laura Campbell-Sills, Robert J. Ursano, et al
JCP
Original Research

May 23, 2018

Hoarding is common in the elderly and is often coupled with physical and medical problems in this population. Read this article to see if Cognitive Rehabilitation and Exposure/Sorting Therapy...
Catherine R. Ayers, Mary E. Dozier, Elizabeth W. Twamley, et al
JCP
Original Research

May 22, 2018

How do mental health clinicians define their role in treating decisionally capable patients with advanced medical illness who wish to die? Read this narrative review to learn about different...
Joel Yager, Linda Ganzini, Dan H. Nguyen, et al
JCP
Original Research

May 22, 2018

Finding effective treatment for depressed patients who do not adequately respond to antidepressant medications is a frequent challenge for clinicians. Read this article to learn about the efficacy, safety,...
Mary Hobart, Aleksandar Skuban, Peter Zhang, et al
JCP
Original Research

May 15, 2018

The use of antidepressants in the treatment of bipolar disorder can lead to antidepressant-induced mania (AIM)—but not in every case. This article explores the risk factors that might increase...
Aislinn J. Williams, Zongshan Lai, Seth Knight, et al
JCP
Original Research

May 15, 2018

The currently available dopamine-blocking antipsychotics haven' t been of much help with cognitive deficits in schizophrenia. This post hoc analysis of an RCT examines whether MIN-101, which combines sigma-2...
Richard S. E. Keefe, Philip D. Harvey, Anzalee Khan, et al
JCP
Original Research

May 8, 2018

Read a full report on the clinical features of Lewy Body Dementia (LBD) auditory hallucinations and the possible mechanisms they arise in patients.
Naoko Tsunoda, Mamoru Hashimoto, Tomohisa Ishikawa, et al
JCP
Original Research

May 1, 2018

Anecdotal evidence suggests that risk factors related to type 2 diabetes mellitus—including obesity, hypertension, and dyslipidemia—may be associated with attention-deficit/hyperactivity disorder. This study looked at this possible relationship more...
Mu-Hong Chen, Tai-Long Pan, Ju-Wei Hsu, et al
JCP
Original Research

May 1, 2018

Ketamine has shown promise in treating depression and posttraumatic stress disorder (PTSD) individually. This article examines repeated ketamine infusions for individuals with comorbid treatment-resistant depression and PTSD—read it to...
C. Sophia Albott, Kelvin O. Lim, Miriam K. Forbes, et al
JCP
Original Research

April 24, 2018

Cognitive impairment is among the many possible damaging outcomes of war captivity and PTSD. This study of 95 Israeli ex-POWs from the 1973 Yom Kippur War looked at the...
Roy Aloni, Laura Crompton, Yafit Levin, et al
JCP
Original Research

April 24, 2018

Given the high rates of overdose in young people, understanding the risk factors for it in youth with substance use disorders is important. This medical record review of 200...
Amy M. Yule, Nicholas W. Carrellas, Maura Fitzgerald, et al
JCP
Original Research

April 17, 2018

How does a patient's resilience level and history of childhood adversity impact his or her health? This study evaluated 114 schizophrenia patients and 101 comparison subjects to determine the...
Ellen E. Lee, Averria Sirkin Martin, Xin Tu, et al
JCP
Original Research

April 17, 2018

Read a study on the effects of rTMS on suicidal ideation in patients with treatment-resistant major depression (TRD).
Cory R. Weissman, Daniel M. Blumberger, Patrick E. Brown, et al
JCP
Original Research

April 17, 2018

The relationship between insight and suicide in patients with schizophrenia is unclear. Read this article to learn the extent to which that relationship may be influenced by quality of...
Paul Roux, David Misdrahi, Delphine Capdevielle, et al
JCP
Original Research

April 10, 2018

Do differences exist in the likelihood of taking antipsychotic medication between patients with schizophrenia in rural areas and those in urban communities? Read this article to learn about the...
Cai-Lan Hou, Miao-Yang Chen, Mei-Ying Cai, et al
JCP
Original Research

April 10, 2018

Impulse-control disorders (ICDs) have been noted anecdotally in patients with Parkinson's disease, but what is their true prevalence? To estimate this prevalence, this study compared the frequency of ICDs...
Maria Rita Lo Monaco, Martina Petracca, Daniel Weintraub, et al
JCP
Original Research

April 10, 2018

Despite the interest in the association of inflammation with depression, anti-inflammatory markers have received little research attention with regard to depression risk. This study enrolled euthymic community-dwelling elderly Korean...
Dae Jong Oh, Ji Won Han, Beom Jun Min, et al

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