Original Research

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Posts about this type

JCP
Original Research

April 3, 2018

Current treatment guidelines recommend limiting the use of antipsychotic medications in patients with Alzheimer's disease except briefly and only at low doses. But do antipsychotics actually lead to increased...
René Ernst Nielsen, Jan B. Valentin, Annette Lolk, et al
JCP
Original Research

April 3, 2018

Impaired executive function often accompanies depression in older adults. Can executive dysfunction lead to decreased response to antidepressant treatment? Read this article to learn more about the relationship between...
Pilar Cristancho, Eric J. Lenze, David Dixon, et al
JCP
Original Research

April 3, 2018

Comorbid psychiatric illness can negatively impact compliance with antiretroviral treatment (ART) in HIV-infected patients. This French study used data from a large national survey to determine if PTSD and...
Perrine Roux, Fabienne Marcellin, Khadim Ndiaye, et al
JCP
Original Research

March 27, 2018

PTSD is more prevalent in women than in men, but is this because women's exposure to traumatic events is greater or because they are more vulnerable to traumatic events?...
Carlos Blanco, Nicolas Hoertel, Melanie M. Wall, et al
JCP
Original Research

March 20, 2018

Recent studies aimed at the development of personalized pharmacotherapy have identified CYP enzymes and transporters as important determinants of variability in drug disposition and response. Along these lines, this...
Célia Lloret-Linares, Marija Bosilkovska, Youssef Daali, et al
JCP
Original Research

March 20, 2018

For preventing prescription drug misuse in young adults, it's important to know the source from which they obtained the drugs. This study used data from a large nationally representative...
Sean Esteban McCabe, Christian J. Teter, Carol J. Boyd, et al
JCP
Original Research

March 13, 2018

While stimulants are the mainstay of ADHD treatment, their use is marred by concerns about substance abuse. This study involving  37 adults with ADHD looks at whether naltrexone might...
Thomas J. Spencer, Pradeep Bhide, Jinmin Zhu, et al
JCP
Original Research

March 13, 2018

Although some studies suggest that excessive brain opioid activity may affect or even determine the pathogenesis of autism, discrepancies exist between results of individual studies. Read this article to...
Sylvie Tordjman, George M. Anderson, Anna׫lle Charrier, et al
JCP
Original Research

March 13, 2018

Because suicide loss survivors are susceptible to developing complicated grief, identifying effective treatments for suicide loss survivors with complicated grief is crucial. Read this article to learn if adding...
Sidney Zisook, M. Katherine Shear, Naomi M. Simon, et al
JCP
Original Research

March 6, 2018

Cigarette smokers are more likely than nonsmokers to use cannabis, and cannabis users are cigarette smokers more often than are nonusers. Read this article to learn how cannabis use...
Andrea H. Weinberger, Jonathan Platt, Jan Copeland, et al
JCP
Original Research

February 27, 2018

Although electroconvulsive therapy is the most robust acute treatment for MDD, nearly one-third of patients don' t respond to it—but why? This study investigated C-reactive protein and interleukin-6, both...
Jennifer L. Kruse, Eliza Congdon, Richard Olmstead, et al
JCP
Original Research

February 27, 2018

Even though methylphenidate is the most commonly prescribed medication for ADHD, not all ADHD patients respond to this agent equally. Can sluggish cognitive tempo—sluggishness, sleepiness, and/or "daydreaminess"—affect methylphenidate response?...
Tanya E. Froehlich, Stephen P. Becker, Todd G. Nick, et al
JCP
Original Research

February 27, 2018

Clinical heterogeneity is a key challenge to understanding suicidal risk, as different pathways to suicidal behavior exist. Discover the latent classes of late-life depression in this longitudinal study examining...
Katalin Szanto, Hanga Galfalvy, Polina M. Vanyukov, et al
JCP
Original Research

February 20, 2018

Read why treatment resistant depression, even compared to MDD, poses a significant direct and indirect cost burden to US employers and employment status.
Tony B. Amos, Neeta Tandon, Patrick Lefebvre, et al
JCP
Original Research

February 20, 2018

Youth who are at risk for relapse of MDD may benefit from treatment strategies aimed at preventing the return of symptoms. This study looked at clinical characteristics associated with...
Beth D. Kennard, Taryn L. Mayes, Zohra Chahal, et al
JCP
Original Research

February 20, 2018

People at risk of Alzheimer's disease often have higher functional connectivity in several brain networks. Does this functional connectivity change over time—and is there a pattern of change specific...
Qing Ye, Haifeng Chen, Fan Su, et al
JCP
Original Research

February 13, 2018

Because recent research supports the effectiveness of antipsychotics in nonresponsive major depressive disorder, examining national prescribing trends for these drugs in MDD is a timely topic. Using data from...
Taeho Greg Rhee, Somaia Mohamed, Robert A. Rosenheck
JCP
Original Research

February 13, 2018

Adventurous and explosive temperament profiles have been associated with antisocial and borderline personality disorders. This analysis of over 2,000 participants in the Young Finns study looks at whether these...
Aino I. L. Saarinen, Tom H. Rosenström, Christian A. Hakulinen, et al
JCP
Original Research

February 6, 2018

Clinicians often have little direction regarding optimal treatment options for obsessive-compulsive disorder (OCD). Read this article to learn the relative effectiveness of 7 strategies for treating OCD.
Sean T. Gregory, Brian Kay, Joseph Smith, et al
JCP
Original Research

January 23, 2018

The Maudsley Staging Method has been validated as a way to quantify and predict depression course and outcome, but its generalizability to a community-based population had not yet been...
Sjoerd M. van Belkum, Hanneke Geugies, Thom S. Lysen, et al
JCP
Original Research

January 16, 2018

Early behavioral variant frontotemporal dementia (bvFTD) is often mistaken for major depressive disorder. Could patients' processing of facial emotions provide clues to differentiate the two? In this study, patients...
Isabelle Chiu, Olivier Piguet, Janine Diehl-Schmid, et al
JCP
Original Research

January 9, 2018

The self-report Concise Associated Symptoms Tracking Scale (CAST-SR) was designed to track symptoms such as mania and anxiety in depressed outpatients being treated with antidepressants. This study used data...
Joseph M. Trombello, Michael O. Killian, Allen Liao, et al
JCP
Original Research

January 9, 2018

Little is known about restless legs syndrome in pediatric populations. A survey of 11,831 adolescents that probed symptoms of restless legs syndrome, as well as sleep duration, sleep problems,...
Xianchen Liu, Hua Chen, Zhen-Zhen Liu, et al
JCP
Original Research

January 2, 2018

Sleep problems are more prevalent in children with autism spectrum disorders than in children with typical development. Could sleep problems in infancy serve as an early indicator of atypical...
A. K. Danny Nguyen, Laura E. Murphy, Mehmet Kocak, et al

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