The Failure of Evidence-Based Medicine to Guide Treatment of Antidepressant Nonresponders

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Depression is one of the world’s greatest healthproblems,¹ and prompt recognition and vigorous treatment to remission are the best means to reduce theglobal illness burden, increased mortality, and untold sufferingassociated with depressive disorders. As I have reviewedelsewhere, dozens of randomized controlled trials(RCTs) have documented that antidepressant pharmacotherapy,the most widely used treatment for depression,has limited efficacy.^2-5‘ ‹