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Where Autoantibodies Strike in Anti-NMDAR Encephalitis
news

January 26, 2026

A new study shows that antibodies in anti-NMDAR encephalitis target exposed hotspots on NMDA receptors, explaining synaptic disruption.
JCP
Rethinking Amisulpride: Could N-Methylation Result in a New and Even Better Antipsychotic?
ASCP Corner

January 26, 2026

This article will familiarize US clinicians with amisulpride’s history and data, and the rationale behind development of LB-102, an N-methylated analogue of amisulpride.
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JCP
Urological Commentary on Ketamine-Associated Uropathy
Letter to the Editor

January 26, 2026

The author comments on a recent article reviewing ketamine-associated uropathy in therapeutic and nontherapeutic settings.
JCP
Ketamine-Associated Uropathy in Therapeutic Contexts: Reply to Abdelrahman
Letter to the Editor

January 26, 2026

Dr Andrade responds to a letter commenting on his recent review of ketamine-associated uropathy in therapeutic and nontherapeutic settings.
Weekly Mind Reader: When Antidepressants Fail
news

January 23, 2026

New Mayo Clinic guidance stresses patient care, while studies examine veterans’ cannabis use and reject lowering the DSM-5-TR mixed-features threshold.
How Delusions Take Shape
news

January 22, 2026

A new study finds that early psychosis delusions emerge as emotionally grounded, embodied responses shaped by lived experience and relationships.

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Autistic and Non-Autistic Faces May ‘Speak Different Languages’

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Next-Step Treatment Options for Treatment-Resistant Depression
Consensus Statement

January 21, 2026

Strong consensus emerged for augmentation with second-generation antipsychotics, TMS, and ketamine/esketamine in the base vignette. Preferences shifted to include non-augmentative antidepressants and ECT based on patient characteristics.
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JCP
How Many Criteria Should be Required to Define the DSM-5 Mixed Features Specifier in Depressed Patients?
Original Research

January 21, 2026

In a study of 459 depressed patients, results did not support lowering the DSM-5-TR diagnostic threshold for the mixed features specifier from 3 to 2 criteria.
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The Primary Care Companion for CNS Disorders

The Primary Care Companion for CNS Disorders seeks to advance the clinical expertise of primary care physicians and other health care professionals who treat patients with mental and neurologic illnesses.

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Basal Ganglia Stroke With Lower Motor Neuron Features
Case Report

January 22, 2026

A 60-year-old man exhibited left-sided toe walking and right-sided weakness despite previous history of left sided basal ganglia stroke, challenging the notion that adult toe walking is a hallmark…
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PCC
Benign Ethnic Neutropenia and Clozapine
Case Report

January 22, 2026

This case highlights the importance of recognizing benign ethnic neutropenia to prevent unnecessary clozapine discontinuation.
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Consensus Report on XT Use in Practice

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