Alleviation of Hot Flashes With Increase in Venlafaxine Dose

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Sir: Venlafaxine, a newer bicyclic antidepressant, acts as aserotonin-norepinephrine reuptake inhibitor (SNRI). Besidesimproving depressive symptoms, venlafaxine has also beendemonstrated to alleviate vasomotor symptoms.¹ It is being increasinglyused as a nonhormonal drug to treat hot flashes,mostly in those women with concerns about or contraindicationsto estrogen-containing preparations.²