The Use of Alosetron to Treat SSRI-Induced Gastrointestinal Symptoms

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Sir: The use of selective serotonin reuptake inhibitors (SSRIs) across a wide range of psychiatric disordersis well documented in the literature.¹ The SSRIs are generally well tolerated and dosed once daily, features thatenhance compliance.² However, among the common side effects of SSRIs are gastrointestinal reactions includingnausea, diarrhea, loose stools, and constipation.³