Dr. Berigan Replies: Discontinuation of Therapy with Bupropion SR

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Sir: Dr. Johnson’s interest in our reported case of bupropion-associated withdrawal symptoms isgreatly appreciated. As was pointed out in the case report, the exact mechanism responsible for thesomatic and psychological symptoms is not known. It is believed that many neurotransmitters may beinvolved, including the noradrenergic and dopaminergic sites, which appear to be where bupropion exertsits effects.¹