A Case Report of Seizure Induced by Bupropion Nasal Insufflation

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Sir: Bupropion hydrochloride (HCl) is an aminoketone antidepressant currently approved by the U.S. Food and Drug Administration (FDA) for depression and smoking cessation. Off-label uses include treatment of attentiondeficit/ hyperactivity disorder, chronic fatigue, and cocaine dependence and adjunctive treatment for Parkinson’s disease. Bupropion is available in 3 formulations: immediaterelease (IR), sustained-release (SR), and extended-release (XL).