Discontinuation of Therapy With Bupropion SR

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Sir: In the April 1999 issue of the Companion, Drs. Berigan and Harazin1 report a case of possiblebupropion-associated withdrawal symptoms in a patient treated for smoking cessation. The authorsdescribe the emergence of a number of symptoms following abrupt discontinuation of bupropionsustained-release (SR). The occurrence of withdrawal symptoms or a discontinuation syndrome withbupropion has been extensively evaluated in smoking cessation and depression development programsinvolving over 10,000 patients. In clinical trials (references 2 and 3 and Glaxo Wellcome Inc., data onfile), patients were monitored for the emergence of posttreatment adverse events 1 week after abruptdiscontinuation of therapy.