Introduction. Emerging Evidence in the Treatment of Depression and Chronic Pain in Primary Care: All Antidepressants Are Not Created Equal

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Depression is one of the leading causes of global disease burden and is expected to be the second leading cause within 2 decades.¹There is a vast body of evidence to demonstrate the potential effects of untreated or inadequately treated depression, including an increased likelihood of negative outcomes in comorbid medical conditions^2-5 and increased health care costs,^6,7 as well as outcomes specific to depression, such as significant psychosocial impairment,^6,8-10 an increased risk of relapse or recurrence, a longer time to recovery, and a shorter time between episodes.^11-14