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Premenstural dysphoric disorder (PMDD) affects 3% to 8% of women with regular menstrual cycles. Symptoms of PMDD include a range of emotional and somatic symptoms that are limited to the luteal phase of the menstrual cycle (the last 14 days prior to menses) and that interfere with occupational and social functioning. Clinicians who care for women must differentiate PMDD from a spectrum of other conditions that may present with similar symptoms. PMDD is a discrete diagnostic entity with attendant suffering and impairment of functioning.