The Primary
Care Companionfor CNS Disorders

Advancing primary care with essential peer-reviewed research and insights into CNS disorders

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PCC
Antihistamines: Indications, Interactions, and Adverse Effects
Rounds in the General Hospital

Antihistamines: Indications, Interactions, and Adverse Effects

September 16, 2025

Many antihistamines share a propensity for muscarinic receptor antagonism at higher doses, leading to symptoms of anticholinergic toxicity.
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PCC
Amnesia Associated With Recreational Cannabis Use in an Adolescent
Case Report

Amnesia Associated With Recreational Cannabis Use in an Adolescent

September 16, 2025

A 17-year-old girl with no prior psychiatric or medical history presented to the psychiatry ED for confusion and agitation following recent cannabis use.
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PCC
Knowledge of ECT for Catatonia
Letter to the Editor

Knowledge of ECT for Catatonia

September 11, 2025

The authors comment on a recent study by Kaur et al assessing what internists and neurologists know about catatonia.
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PCC
Mental Health Impact of COVID-19 Pandemic on the Mental Health of Middle-Aged and Older Adults: A Cross-sectional, Comparative Study
Original Research

Mental Health Impact of COVID-19 Pandemic on the Mental Health of Middle-Aged and Older Adults: A Cross-sectional, Comparative Study

September 11, 2025

Older adults were found to have less depression and anxiety compared to middle-aged adults; loneliness and perception of knowledge about COVID can affect the association between the presence of…
, , , et al
PCC
Knowledge of Catatonia: Reply to Espinoza and Kellner
Letter to the Editor

Knowledge of Catatonia: Reply to Espinoza and Kellner

September 11, 2025

The authors reply to a letter to the editor commenting on their article.
, , , et al
PCC
Precision Psychiatry for Depression Treatment
Narrative Review

Precision Psychiatry for Depression Treatment

September 9, 2025

Novel precision medicine tools in depression aim to identify the optimal treatment for each patient and have the potential to significantly improve depression management by guiding treatment selection for…
, , , et al
PCC
Navigating Bell’s Mania and Catatonia
Case Report

Navigating Bell’s Mania and Catatonia

September 9, 2025

A healthy 17-year-old boy with no psychiatric family history experienced stress-induced, acute-onset catatonia and Bell’s mania.
, , , et al
PCC
Incretin Therapies: A New Tool to Combat Metabolic Consequences of Antipsychotic Use
Narrative Review

Incretin Therapies: A New Tool to Combat Metabolic Consequences of Antipsychotic Use

September 4, 2025

Incretin therapies have emerged as a promising treatment option with potential benefits for mitigating cardiometabolic side effects associated with antipsychotics; however, clinical trials have often excluded psychiatric populations.
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PCC
Neurobehavioral Symptoms and Machado Joseph Disease
Case Report

Neurobehavioral Symptoms and Machado Joseph Disease

September 2, 2025

The authors highlight the neuropsychiatric symptomology of Machado Joseph Disease and how management may be approached in older adult patients who might struggle with similar acute-onset psychiatric concerns.
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PCC
Predictors of Depression Response in a Community ECT Clinic
Original Research

Predictors of Depression Response in a Community ECT Clinic

August 28, 2025

Anxiety symptoms may be a factor correlated with depression treatment response, suggesting potential utility in screening for anxiety symptoms in assessing likelihood of success with ECT treatment.
, , , et al
PCC
It Takes a Village: A Multidisciplinary Approach to Catatonia in Pregnancy
Case Report

It Takes a Village: A Multidisciplinary Approach to Catatonia in Pregnancy

August 26, 2025

Timely treatment of catatonia is crucial and outweighs the risk of exposure to the fetus.
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PCC
Psychosis Due to Cushing Syndrome
Case Report

Psychosis Due to Cushing Syndrome

August 21, 2025

Acute psychosis may be the initial manifestation of Cushing syndrome, but it can easily be overlooked, especially in patients with preexisting psychiatric conditions.
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