The Primary
Care Companionfor CNS Disorders

Advancing primary care with essential peer-reviewed research and insights into CNS disorders

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More Articles from The Primary Care Companion for CNS Disorders

PCC
Mania and Cerebral Amyloid Angiopathy
Case Report

Mania and Cerebral Amyloid Angiopathy

March 19, 2026

This report details a case in which a patient presented with mania in the setting of cerebral amyloid angiopathy and hypertension that did not abate until treatment with antihypertensives.
, , , et al
PCC
Atypical Presentation of Autoimmune Encephalitis
Case Report

Atypical Presentation of Autoimmune Encephalitis

March 19, 2026

A 23-year-old woman presented with probable antibody-negative autoimmune encephalitis that initially mimicked a primary psychiatric disorder.
, , , et al
PCC
Recreational Ketamine-Induced Uropathy
Brief Report

Recreational Ketamine-Induced Uropathy

March 19, 2026

Two patients with chronic recreational ketamine use presented with urinary frequency, urgency, dysuria, and hematuria in the absence of infection.
, , , et al
PCC
Tacrolimus-Induced Parasomnia Posttransplantation
Case Report

Tacrolimus-Induced Parasomnia Posttransplantation

March 17, 2026

The authors present a rare case of tacrolimus-induced parasomnia, adding to the body of evidence on its neurotoxic potential.
, , , et al
PCC
Clozapine-Induced Antiphospholipid Syndrome
Case Report

Clozapine-Induced Antiphospholipid Syndrome

March 12, 2026

A 68-year-old man with no pre‐existing risk factors experienced clozapine-induced antiphospholipid syndrome and a deep vein thrombosis.
, ,
PCC
Ultra–Low-Dose Mirtazapine for Chronic Insomnia
Original Research

Ultra–Low-Dose Mirtazapine for Chronic Insomnia

March 10, 2026

In patients with insomnia disorder, a clinically relevant effect was seen with low-dose mirtazapine (3.75 mg) on insomnia severity from 1–3 months.
, , , et al
PCC
Administering ECT to Critically Ill Patients
Rounds in the General Hospital

Administering ECT to Critically Ill Patients

March 5, 2026

ECT can be lifesaving for critically ill individuals with severe psychiatric and neuropsychiatric conditions; however, cardiac monitoring is essential.
, , , et al
PCC
Caffeine for ICI Encephalitis
Case Report

Caffeine for ICI Encephalitis

March 5, 2026

With the increased use of immune checkpoint inhibitors, the potential for aseptic encephalitis poses a unique challenge to patient rehabilitation.
, , , et al
PCC
Misophonia With Psychiatric Comorbidities
Case Report

Misophonia With Psychiatric Comorbidities

March 3, 2026

This case highlights the need for enhanced recognition of misophonia, integrated care pathways, and improved mental health infrastructure in low- and middle-income countries.
PCC
Depression and Cardiovascular Disease in Aging Populations
Original Research

Depression and Cardiovascular Disease in Aging Populations

March 3, 2026

Even infrequent depressive symptoms are associated with elevated CVD risk in older adults, and those with both depressive symptoms and obesity or smoking have higher odds.
, , , et al
PCC
Intranasal Tapentadol Dependence
Case Report

Intranasal Tapentadol Dependence

February 26, 2026

The authors present 2 cases of intranasal tapentadol dependence marked by rapid tolerance and significant physical and psychological issues.
, , , et al
PCC
Practice Relevance as the North Star: A Message From the Editor
Editorial

Practice Relevance as the North Star: A Message From the Editor

February 26, 2026

Dr Culpepper, Editor in Chief, outlines manuscript selection criteria for the PCC, prioritizing clinical relevance to primary care and frontline psychiatric settings, and thanks peer reviewers for their service.

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