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Rounds in the General Hospital

PCC
Clozapine: Its Use and Monitoring
Rounds in the General Hospital

July 30, 2024

The authors provide the latest information on clozapine use, including when your patients should receive or avoid taking it, what laboratory tests are required before and during administration, and…
Desta S. Lissanu, Chirag M. Vyas, Carol S. Lim, et al
PCC
Pharmacologic Management of TBI
Rounds in the General Hospital

July 16, 2024

Cognitive complaints, including difficulties with attention, concentration, and memory, are common in patients post-TBI; however, many medications have been studied in the treatment of cognition after TBI. Read on…
Sofia E. Matta, Christina LaCroix, Kaloyan Tanev, et al
PCC
Evaluation and Management of Treatment-Resistant Schizophrenia
Rounds in the General Hospital

July 2, 2024

If you have ever been uncertain about how to evaluate patients with a chronic psychotic illness or struggled over how best to manage treatment-resistant schizophrenia, then this case vignette…
Carol S. Lim, Abigail L. Donovan, Chirag M. Vyas, et al
PCC
Neuropsychiatric Complications of Hypervitaminosis D
Rounds in the General Hospital

June 13, 2024

A 28-year-old man presented to the emergency department with severe agitation, insomnia, weakness, constipation, and muscle jerks after nonsuicidal overdosing of vitamin D.
James K. Rustad, Adam Z. Spitz, Brandon C. Wilson, et al
PCC
Impact of Disability on Medical Care
Rounds in the General Hospital

June 6, 2024

Given that many people have disabilities, physicians should develop skills that assess the level of disability, the functional consequence of illness, and the social and physical environments of patients…
Mirza Baig, Andrew S. Chun, Ashika Bains, et al
PCC
Management of Rumination and Obsessions in Primary Care
Rounds in the General Hospital

May 30, 2024

Difficult-to-control negative repetitive thoughts can manifest as ruminations or obsessions. Appropriate early identification and intervention can positively affect the course and prevent an episode of psychiatric illness.
Sharmin Ghaznavi, Charlotte Schiewe, Theodore A. Stern

Page 5

More PCC Articles

JCP
Relationship of Anxious Arousal with Treatment of Dysphoria Using VR Mindfulness and 2 Accelerated TMS Protocols
Original Research

May 22, 2024

Baseline levels of anxious arousal were not predictive of outcomes of treatment with VR or accelerated TMS.
Austin M. Spitz, Megan C. Senda, Kevin A. Johnson, et al
JCP
Emotional Neglect and Inflammatory Ratios in First-Episode Psychosis
Original Research

May 22, 2024

The authors examined the link between the immune system and childhood traumatic events in patients with first-episode psychosis.
Oriol Cuñat, Belén Arranz, Regina Vila-Badia, et al
JCP
Psychosis, Inflammatory Biomarkers, and Subtypes of Childhood Trauma
Commentary

May 22, 2024

Dr Nasrallah discusses a recent study by Cuñat et al of the relationship between childhood trauma and inflammation, and why this work is unique and important.
Henry A. Nasrallah
JCP
Pilot Study of High Frequency TMS for Bipolar Depression
Original Research

May 20, 2024

In this study of patients with bipolar depression, 87.1% reached response and 74.2% reached remission with 6 weeks of rTMS.
Scott T. Aaronson, Eric L. Goldwaser, Paul E. Croarkin, et al
JCP
Clinical Index to Discriminate Between MCI and Mild Dementia
Original Research

May 20, 2024

A combined index from the MMSE and Lawton Index performed well in discriminating between Clinical Dementia Rating scores of 0.5 and 1.
Kazuaki Uchida, Taiki Sugimoto, Kenta Murotani, et al
JCP
Antipsychotic Medication Continuation vs Taper and Discontinuation
Clinical and Practical Psychopharmacology

May 15, 2024

Dr Andrade discusses two studies that examined the outcomes of gradual, individualized antipsychotic dose reduction and discontinuation in patients with psychosis.
Chittaranjan Andrade
JCP
Clozapine Exposure and Risk of Hematologic Malignancies in Veterans with Schizophrenia
Original Research

May 15, 2024

Clozapine exposure of at least 5 years was associated with hematologic malignancy, and the increased risk was dose-dependent.
Delaney R. Brainerd, Bruce Alexander, Marshall J. Tague, et al
JCP
Effects of a Multicomponent Intervention for Older Adults at Risk of Dementia
Original Research

May 13, 2024

This randomized controlled trial of cognitive training plus lifestyle guidance demonstrated improved cognitive function in community-dwelling older adults at risk of dementia.
Pengfei Wang, Tingting Yang, Wenjia Peng, et al
JCP
Effect of Time From Onset of MDD on Response to Esmethadone
Original Research

May 13, 2024

Esmethadone 25 and 50 mg were more effective in reducing depression scale scores in patients who had a shorter time since their first major depressive episode.
Clotilde Guidetti, Sara De Martin, Giulia Serra, et al
JCP
Barriers to Esketamine Nasal Spray Use in Treatment-Resistant Depression
Original Research

May 6, 2024

Potential barriers to treatment with esketamine nasal spray include travel distance, insurance, low socioeconomic status, and minority communities.
Kruti Joshi, Joshua N. Liberman, Purva Parab, et al
JCP
Concomitant LAIs and Time to Rehospitalization in Patients Receiving Clozapine
Original Research

May 1, 2024

Clozapine plus LAI antipsychotics was associated with lower risk of rehospitalization compared to both clozapine plus oral antipsychotics and clozapine monotherapy.
Yun Tien, Xi-Yu Wang, Shang-Chien Huang, et al
JCP
Clozapine Use and Specific Indications
Original Research

April 29, 2024

Clozapine initiation is uncommon in people with psychotic disorders who have experienced events suggesting clozapine is indicated, with even lower rates in Black and Hispanic patients.
Gregory E. Simon, Rebecca C. Rossom, Esti Iturralde, et al

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