Case Report July 12, 2022

Phenibut and Bromazolam Use Disorders Requiring Hospitalization for Medically Supervised Withdrawal

Sean McDermott, BS; Benjamin E. Johnson, MS; Alëna A. Balasanova, MD

Prim Care Companion CNS Disord 2022;24(4):21cr03119

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  1. Sullivan JT, Sykora K, Schneiderman J, et al. Assessment of alcohol withdrawal: the revised Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar). Br J Addict. 1989;84(11):1353–1357.
  2. Lapin I. Phenibut (β-Phenyl-GABA): a tranquilizer and nootropic drug. CNS Drug Rev. 2006;7(4):471–481.
  3. Jouney EA. Phenibut (β-Phenyl-γ-Aminobutyric Acid): an easily obtainable “dietary supplement” with propensities for physical dependence and addiction. Curr Psychiatry Rep. 2019;21(4):23.
  4. Mash JE, Leo RJ. Phenibut: a novel nootropic with abuse potential. Prim Care Companion CNS Disord. 2020;22(4):19l02587.
  5. Graves JM. Notes from the field: phenibut exposures reported to poison centers—United States, 2009–2019. MMWR Morb Mortal Wkly Rep. 2020;69(35):1227–1228. Accessed August 27, 2021. https://www.cdc.gov/mmwr/volumes/69/wr/mm6935a5.htm
  6. Samokhvalov AV, Paton-Gay CL, Balchand K, Rehm J. Phenibut dependence. BMJ Case Rep. 2013:bcr2012008381.
  7. Hardman MI, Sprung J, Weingarten TN. Acute phenibut withdrawal: a comprehensive literature review and illustrative case report. Bosn J Basic Med Sci. 2018;19(2):125–129.
  8. Brunner E, Levy R. Case report of physiologic phenibut dependence treated with a phenobarbital taper in a patient being treated with buprenorphine. J Addict Med. 2017;11(3):239–240.
  9. PubChem. 8-Bromo-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine. pubchem.ncbi.nlm.nih.gov website. Accessed August 18, 2021.  https://pubchem.ncbi.nlm.nih.gov/compound/12562546
  10. PubChem. Alprazolam. @pubchem. PubChem website. Accessed August 18, 2021. https://pubchem.ncbi.nlm.nih.gov/compound/Alprazolam#section=Structures
  11. Zawilska JB, Wojcieszak J. An expanding world of new psychoactive substances—designer benzodiazepines. Neurotoxicology. 2019;73:8–16.
  12. TripSit Factsheets. drugs.tripsit.me website. Accessed August 18, 2021. http://drugs.tripsit.me/
  13. Bromazolam vad vet vi om denna? (rc benso). flashback.org website. Accessed August 18, 2021. https://www.flashback.org/t2805274
  14. Manchester KR, Lomas EC, Waters L, et al. The emergence of new psychoactive substance (NPS) benzodiazepines: a review. Drug Test Anal. 2017;10(1):37–53.