Possible New Causes For False-Positive Diagnosis of Pheochromocytoma: Lamotrigine, Aripiprazole, or the Combination

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Sir: Pheochromocytomas are rare neuroendocrine tumorsdiagnosed by elevated plasma and/or urine catecholamines ortheir metabolites.^1,2 Medications reported to cause false-positiveserum or urine studies include acetaminophen, phenoxybenzamine,amitriptyline, labetolol, haloperidol, levodopa, tamsulosin,venlafaxine, hydrochlorothiazide, and buspirone.^2,3 Wereport a case in which lamotrigine, aripiprazole, or both causedsymptoms and biochemical evidence suggesting pheochromocytomathat resolved when the drugs were discontinued.